I'd suggest the key "W3svc/IIs5IsolationModeEnabled" of metabase will need
one restart of IIS which is located in the service tab of site property
from the IIS mmc.
That being said, most application pool properties require that the app pool
itself be restarted. When an admin changes an app pool property, IIS will
restart the app pool (and corresponding worker process) automatically. If
they do not wish for this to happen, they need to set
disallowrotationonconfigchange to true for that app pool only. Doing so
means that any change to the properties of an application pool will not
take affect until the admin recycles that app pool himself. In normal
situations, there should be no need to change this property. The
auto-recycle of an app pool happens so fast that there should be no loss in
service for any users.
Furthermore, I'd suggest you can use IIS metabase explorer to check the
metabase which can be obtained from IIS6 resource kit. Please go to:
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