Actually the room has as much effect as the speakers so without a properly
designed room, the question is sort of moot. In my computer studio I simply
use a Yamaha system designed for the computer that has a powered subwoofer.
I allow my sound cards to shape the sound and keep the speaker output flat.
When doing serious mixing, I always use headphones. Then I test the CD out
in various modes, big room, small room, home stereo, club system, auto,